The average bus between Saint Louis University and Chicago takes 6h 43m and the fastest bus takes 6h 34m. The bus service runs several times per day from Saint Louis University to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Saint Louis University and Chicago. The earliest departure is at 9:10 AM in the morning, and the last departure from Saint Louis University is at 11:11 PM which arrives into Chicago at 5:45 AM. All services require a transfer at Lindell @ Grand Eb and take an average of 6h 43m. The schedules shown below are for the next available departures.

6h 46m • 1 change

6h 46m • 1 change
Arrives next day

6h 34m • 1 change

6h 46m • 1 change

6h 46m • 1 change
Arrives next day

6h 34m • 1 change

6h 46m • 1 change

6h 46m • 1 change
Arrives next day

6h 34m • 1 change

6h 46m • 1 change

6h 46m • 1 change
Arrives next day

6h 34m • 1 change
Want to know about travelling from Saint Louis University to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Saint Louis University to Chicago. However, there are services departing from Saint Louis University station and arriving at Chicago station via Chicago Bus Station station. The journey, including transfers, takes approximately 6h 43m.
Saint Louis University to Chicago bus services, operated by Metro St. Louis, depart from St Louis Bus Station.
Saint Louis University to Chicago bus services, operated by Metro St. Louis, arrive at Chicago Bus Station.
The distance between Saint Louis University and Chicago is 422.7 km. The road distance is 513 km.
Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station twice daily. Tickets cost $50–85 and the journey takes 6h 5m.