The average bus between San Antonio and DeSoto takes 8h 1m and the fastest bus takes 6h 25m. The bus service runs several times per day from San Antonio to DeSoto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between San Antonio and DeSoto. The earliest departure is at 12:40 AM at night, and the last departure from San Antonio is at 6:35 PM which arrives into DeSoto at 6:15 AM. All services require a transfer at Dallas Bus Station and take an average of 8h 1m. The schedules shown below are for the next available departures.

6h 25m • 1 change

7h 19m • 1 change

6h 40m • 1 change
Arrives next day

11h 40m • 1 change

6h 25m • 1 change

7h 19m • 1 change

6h 40m • 1 change
Arrives next day

11h 40m • 1 change

6h 25m • 1 change

7h 19m • 1 change

6h 40m • 1 change
Arrives next day

11h 40m • 1 change
Want to know about travelling from San Antonio to DeSoto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Antonio to DeSoto. However, there are services departing from San Antonio station and arriving at DeSoto station via Dallas Bus Station station. The journey, including transfers, takes approximately 8h 1m.
San Antonio to DeSoto bus services, operated by Greyhound Mexico, depart from San Antonio Bus Station.
San Antonio to DeSoto bus services, operated by Greyhound Mexico, arrive at Dallas Bus Station.
The distance between San Antonio and DeSoto is 385 km. The road distance is 471 km.
Greyhound-us operates a bus from San Antonio Bus Station to Dallas Bus Station 4 times a day, and the journey takes 5h 5m. Two other operators also service this route.