The average bus between San Antonio and Winston-Salem takes 29h 32m and the fastest bus takes 28h 55m. The bus service runs several times per day from San Antonio to Winston-Salem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between San Antonio and Winston-Salem. The earliest departure is at 1:05 AM at night, and the last departure from San Antonio is at 7:35 AM which arrives into Winston-Salem at 2:45 PM. All services require a transfer at Houston Bus Station and take an average of 29h 32m. The schedules shown below are for the next available departures.
Arrives next day


29h 55m • 2 changes
Arrives next day


31h 10m • 2 changes
Arrives next day


29h 55m • 2 changes
Arrives next day


31h 10m • 2 changes
Arrives next day


29h 55m • 2 changes
Arrives next day


31h 10m • 2 changes
Want to know about travelling from San Antonio to Winston-Salem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Antonio to Winston-Salem. However, there are services departing from San Antonio station and arriving at Winston-Salem station via Houston Bus Station station. The journey, including transfers, takes approximately 29h 32m.
San Antonio to Winston-Salem bus services, operated by Greyhound USA, depart from San Antonio Bus Station.
San Antonio to Winston-Salem bus services, operated by Greyhound USA, arrive at Winston Salem(Trans Center) station.
Book your San Antonio to Winston-Salem bus tickets online with Greyhound USA.
The distance between San Antonio and Winston-Salem is 1,857 km. The road distance is 2,175 km.
You can take a bus from San Antonio Bus Station to Winston Salem(Trans Center) via Houston Bus Station and Atlanta Bus Station in around 28h.