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San Diego to Buffalo buses

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Trip Overview

The bus between San Diego and Buffalo takes 3d 18h. The bus runs, on average, 3 times per week from San Diego to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3d 18h
Duration
2,785 mi
Distance
$591
Average price
3 times a week
Frequency

San Diego to Buffalo bus times

Buses run 3 times a week between San Diego and Buffalo. The service departs San Diego at 10:15 PM at night, which arrives into Buffalo at 20:10:00. All services require a transfer at Los Angeles Union Station and take an average of 3d 18h. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USACOTAFlixbus USA3d 18h • 4 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USACOTAFlixbus USA3d 18h • 4 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USACOTAFlixbus USA3d 18h • 4 changes

Frequently asked questions

Want to know about travelling from San Diego to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from San Diego to Buffalo.ExpandLaunch map view
  • Distance: 2,784.9 mi
  • Duration: 3d 18h

What companies run services between San Diego, CA, USA and Buffalo, NY, USA?

You can take a bus from San Diego to Buffalo via Los Angeles Union Station, St Louis Bus Station, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 2d 15h.

Operators