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San Diego to Key Largo buses

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Trip Overview

The bus between San Diego and Key Largo takes 3d 14h. The bus runs, on average, 4 times per week from San Diego to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3d 14h
Duration
3,127 mi
Distance
$644
Average price
4 times a week
Frequency

San Diego to Key Largo bus times

Buses run 4 times a week between San Diego and Key Largo. The service departs San Diego at 1:10 PM in the afternoon, which arrives into Key Largo at 06:25:00. All services require a transfer at Los Angeles Union Station and take an average of 3d 14h. The schedules shown below are for the next available departures.

Departing Saturday, October 24, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USAGreyhound USAGreyhound USA3d 14h • 4 changes

Departing Sunday, October 25, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USAGreyhound USAGreyhound USA3d 14h • 4 changes

Departing Monday, October 26, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USAGreyhound USAGreyhound USA3d 14h • 4 changes

Frequently asked questions

Want to know about travelling from San Diego to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from San Diego to Key Largo.ExpandLaunch map view
  • Distance: 3,126.8 mi
  • Duration: 3d 14h

What companies run services between San Diego, CA, USA and Key Largo, FL, USA?

You can take a bus from San Diego to Key Largo Bus Stop via Los Angeles Union Station, Dallas Bus Station, Atlanta Bus Station, and Miami Airport Station in around 2d 20h.

Operators