The average bus between San Diego and Otay Mesa takes 1h 33m and the fastest bus takes 1h 14m. There is an hourly bus service from San Diego to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between San Diego and Otay Mesa. The earliest departure is at 3:36 AM at night, and the last departure from San Diego is at 8:32 PM which arrives into Otay Mesa at 9:48 PM. All services require a transfer, and take on average 1h 33m. The schedules shown below are for the next available departures.

1h 18m • 1 change

1h 18m • 1 change

1h 15m • 1 change

1h 16m • 1 change

1h 27m • 1 change

1h 26m • 1 change

1h 30m • 1 change

1h 25m • 1 change

2h 19m • 1 change

1h 14m • 1 change

1h 17m • 1 change

1h 21m • 1 change
Want to know about travelling from San Diego to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Diego to Otay Mesa. However, there are services departing from San Diego station and arriving at Otay Mesa station via Iris Avenue Transit Center. The journey, including transfers, takes approximately 1h 33m.
San Diego to Otay Mesa bus services, operated by San Diego Metro Transit, depart from Broadway & 6th Av station.
San Diego to Otay Mesa bus services, operated by San Diego Metro Transit, arrive at Iris Avenue Transit Center station.
The distance between San Diego and Otay Mesa is 23.5 km. The road distance is 39 km.
San Diego Metro Transit operates a bus from Broadway & 6th Av to Iris Avenue Transit Center every 30 minutes. Tickets cost $2–5 and the journey takes 1h 4m.