The average bus between San Donato Milanese and Siena takes 5h 30m and the fastest bus takes 4h 43m. The bus service runs several times per day from San Donato Milanese to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between San Donato Milanese and Siena. The earliest departure is at 12:46 AM at night, and the last departure from San Donato Milanese is at 11:46 PM which arrives into Siena at 5:30 AM. All services require a transfer, and take on average 5h 30m. The schedules shown below are for the next available departures.

4h 43m • 1 change

6h 2m • 1 change

5h 23m • 1 change

5h 33m • 1 change

4h 43m • 1 change

6h 2m • 1 change

5h 23m • 1 change

5h 22m • 1 change

4h 43m • 1 change

5h 28m • 1 change

5h 22m • 1 change

5h 37m • 1 change
Want to know about travelling from San Donato Milanese to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Donato Milanese to Siena. However, there are services departing from San Donato Milanese station and arriving at Siena station via Siena. The journey, including transfers, takes approximately 5h 30m.
San Donato Milanese to Siena bus services, operated by ATM, depart from Milano, San Donato M3 station.
San Donato Milanese to Siena bus services, operated by ATM, arrive at Siena station.
The distance between San Donato Milanese and Siena is 284.6 km. The road distance is 360 km.
FlixBus operates a bus from Milano, San Donato M3 to Siena 5 times a day. Tickets cost €30–50 and the journey takes 4h 20m.