The average bus between San Fernando and Otay Mesa takes 7h 57m and the fastest bus takes 6h 14m. The bus service runs several times per day from San Fernando to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between San Fernando and Otay Mesa. The earliest departure is at 6:55 AM in the morning, and the last departure from San Fernando is at 6:55 PM which arrives into Otay Mesa at 5:03 AM. All services require a transfer at San Ysidro Transit Center and take an average of 7h 57m. The schedules shown below are for the next available departures.


6h 24m • 2 changes


7h 4m • 2 changes
Arrives next day


10h 8m • 2 changes


6h 24m • 2 changes


7h 4m • 2 changes
Arrives next day


10h 8m • 2 changes


6h 24m • 2 changes


7h 4m • 2 changes
Arrives next day


11h • 2 changes


6h 59m • 2 changes


6h 39m • 2 changes
Arrives next day


11h 15m • 2 changes


6h 14m • 2 changes


6h 54m • 2 changes
Arrives next day


10h 8m • 2 changes
Want to know about travelling from San Fernando to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Fernando to Otay Mesa. However, there are services departing from San Fernando station and arriving at Otay Mesa station via San Ysidro Bus Terminal. The journey, including transfers, takes approximately 7h 57m.
San Fernando to Otay Mesa bus services, operated by Greyhound USA, depart from Los Angeles station.
San Fernando to Otay Mesa bus services, operated by Greyhound USA, arrive at San Ysidro Bus Terminal station.
The distance between San Fernando and Otay Mesa is 233.8 km. The road distance is 297 km.
Greyhound USA operates a bus from Los Angeles to San Ysidro Bus Terminal twice daily. Tickets cost $26–50 and the journey takes 5h 30m. Flixbus USA also services this route once daily.