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San Francisco to Guelph buses

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Trip Overview

The average bus between San Francisco and Guelph takes 3d 20h and the fastest bus takes 3d 17h. The bus runs, on average, 2 times per week from San Francisco to Guelph. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3d 20h
Duration
4,505 km
Distance
$739
Average price
Twice a week
Frequency

San Francisco to Guelph bus times

Buses run twice a week between San Francisco and Guelph. The service departs San Francisco at 1:10 PM in the afternoon, which arrives into Guelph at 09:40:00. All services require a transfer at Sparks Transit Center and take an average of 3d 20h. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

  •  → 

    Arrives +4 days

    Greyhound USAGreyhound USAGreyhound USAFlixbus USAFlixbus USAFlixbus USA3d 17h • 5 changes

Frequently asked questions

Want to know about travelling from San Francisco to Guelph? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from San Francisco to Guelph.ExpandLaunch map view
  • Distance: 4,505 km
  • Duration: 3d 20h

What companies run services between San Francisco, CA, USA and Guelph, ON, Canada?

You can take a bus from San Francisco Bus Station to Guelph via Sparks Transit Center, Denver Union Station, Chicago Bus Station, Detroit Bus Station, and Kitchener in around 2d 16h.

Operators