Rome2Rio

San Francisco to Guelph buses

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Trip Overview

The bus between San Francisco and Guelph takes 4d 4h. The bus runs, on average, 3 times per week from San Francisco to Guelph. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4d 4h
Duration
5,142 km
Distance
$950
Average price
3 times a week
Frequency

San Francisco to Guelph bus times

Buses run 3 times a week between San Francisco and Guelph. The service departs San Francisco at 1:05 AM at night, which arrives into Guelph at 08:10:00. All services require a transfer at Los Angeles Union Station and take an average of 4d 4h. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USABarons BusTrailwaysGO Transit4d 4h • 5 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USABarons BusTrailwaysGO Transit4d 4h • 5 changes

Frequently asked questions

Want to know about travelling from San Francisco to Guelph? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from San Francisco to Guelph.ExpandLaunch map view
  • Distance: 5,142 km
  • Duration: 4d 4h

What companies run services between San Francisco, CA, USA and Guelph, ON, Canada?

You can take a bus from San Francisco to Guelph Central GO Bus via Los Angeles Union Station, St Louis Bus Station, Columbus, Buffalo, Mississauga, and Winston Churchill Transitway Station in around 3d 2h.

Operators