Rome2Rio

San Francisco to Indianapolis buses

Find Transport to Indianapolis

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The bus between San Francisco and Indianapolis takes 2d 10h. The bus runs, on average, 5 times per week from San Francisco to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 10h
Duration
2,536 mi
Distance
$534
Average price
5 times a week
Frequency

San Francisco to Indianapolis bus times

Buses run 5 times a week between San Francisco and Indianapolis. The service departs San Francisco at 1:05 AM at night, which arrives into Indianapolis at 14:30:00. All services require a transfer at Los Angeles Union Station and take an average of 2d 10h. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 10h • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 10h • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 10h • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 10h • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 10h • 2 changes

Frequently asked questions

Want to know about travelling from San Francisco to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from San Francisco to Indianapolis.ExpandLaunch map view
  • Distance: 2,535.7 mi
  • Duration: 2d 10h

What companies run services between San Francisco, CA, USA and Indianapolis, IN, USA?

You can take a bus from San Francisco to Indianapolis Union Station via Los Angeles Union Station and St Louis Bus Station in around 2d 7h.

Operators