Rome2Rio

San Francisco to Key West (Island) buses

Find Transport to Key West (Island)

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Trip Overview

The average bus between San Francisco and Key West (Island) takes 5d 2h and the fastest bus takes 4d 23h. The bus runs, on average, 2 times per week from San Francisco to Key West (Island). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5d 2h
Duration
3,492 mi
Distance
$739
Average price
Twice a week
Frequency

San Francisco to Key West (Island) bus times

Buses run twice a week between San Francisco and Key West (Island). The earliest departure is at 1:05 AM at night, and the last departure from San Francisco is at 7:10 AM which arrives into Key West (Island) at 9:30 AM. All services require a transfer at Los Angeles Union Station and take an average of 5d 2h. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +5 days

    Flixbus USAGreyhound USAGreyhound USAFlixbus USAGreyhound USA4d 23h • 4 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +5 days

    Flixbus USAGreyhound USAGreyhound USAFlixbus USAGreyhound USA5d 5h • 4 changes

Frequently asked questions

Want to know about travelling from San Francisco to Key West (Island)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from San Francisco to Key West (Island).ExpandLaunch map view
  • Distance: 3,492 mi
  • Duration: 5d 2h

What companies run services between San Francisco, CA, USA and Key West (Island), FL, USA?

You can take a bus from San Francisco to Key West Airport via Los Angeles Union Station, Dallas Bus Station, Atlanta Bus Station, and Miami Airport Station in around 3d 5h.

Operators