The average bus between San Francisco and La Mesa takes 17h 42m and the fastest bus takes 14h 47m. The bus runs, on average, 6 times per week from San Francisco to La Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 6 times a week between San Francisco and La Mesa. The earliest departure is at 10:30 PM at night, and the last departure from San Francisco is at 10:30 PM which arrives into La Mesa at 1:17 PM. All services require a transfer at San Diego Greyhound Bus Stop and take an average of 17h 42m. The schedules shown below are for the next available departures.
Want to know about travelling from San Francisco to La Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Francisco to La Mesa. However, there are services departing from San Francisco station and arriving at La Mesa station via San Diego Greyhound Bus Stop. The journey, including transfers, takes approximately 17h 42m.
San Francisco to La Mesa bus services, operated by Greyhound USA, depart from San Francisco Bus Station.
San Francisco to La Mesa bus services, operated by Greyhound USA, arrive at San Diego Greyhound Bus Stop station.
The distance between San Francisco and La Mesa is 741.3 km. The road distance is 866 km.
Greyhound USA operates a bus from San Francisco Bus Station to San Diego Greyhound Bus Stop twice daily. Tickets cost $75–160 and the journey takes 13h 15m.
