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San Luis Obispo to Chicago buses

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Trip Overview

The average bus between San Luis Obispo and Chicago takes 3d 6h and the fastest bus takes 3d 2h. The bus runs, on average, 3 times per week from San Luis Obispo to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3d 6h
Duration
2,407 mi
Distance
$505
Average price
3 times a week
Frequency

San Luis Obispo to Chicago bus times

Buses run 3 times a week between San Luis Obispo and Chicago. The service departs San Luis Obispo at 12:00 PM in the afternoon, which arrives into Chicago at 05:35:00. All services require a transfer at Los Angeles Union Station and take an average of 3d 6h. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAFlixbus USA3d 15h • 2 changes

Departing Tuesday, November 3, 2026

  •  → 

    Arrives +3 days

    Flixbus USAGreyhound USAFlixbus USA3d 2h • 2 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives +3 days

    Flixbus USAGreyhound USAFlixbus USA3d 2h • 2 changes

Frequently asked questions

Want to know about travelling from San Luis Obispo to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from San Luis Obispo to Chicago.ExpandLaunch map view
  • Distance: 2,407.2 mi
  • Duration: 3d 6h

What companies run services between San Luis Obispo, CA, USA and Chicago, IL, USA?

You can take a bus from San Luis Obispo Railroad Museum to Chicago Bus Station via Los Angeles Union Station and St Louis Bus Station in around 2d 4h.

Operators