The average bus between San Mateo Caltrain Station and Santa Clara takes 2h 15m and the fastest bus takes 1h 35m. The bus runs at least 3 times per hour from San Mateo Caltrain Station to Santa Clara. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 20 minutes between San Mateo Caltrain Station and Santa Clara. The earliest departure is at 12:39 AM at night, and the last departure from San Mateo Caltrain Station is at 6:34 PM which arrives into Santa Clara at 8:57 PM. All services require a transfer at 2nd Ave & San Mateo Dr and take an average of 2h 15m. The schedules shown below are for the next available departures.

1h 45m • 1 change

1h 59m • 1 change

2h 9m • 1 change

2h 6m • 1 change
Want to know about travelling from San Mateo Caltrain Station to Santa Clara? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Mateo Caltrain Station to Santa Clara. However, there are services departing from San Mateo Caltrain Station station and arriving at Santa Clara station via Palo Alto Transit Ctr-Bay 1. The journey, including transfers, takes approximately 2h 15m.
San Mateo Caltrain Station to Santa Clara bus services, operated by SamTrans, depart from 2nd Ave & San Mateo Dr station.
San Mateo Caltrain Station to Santa Clara bus services, operated by SamTrans, arrive at El Camino & Scott station.
The distance between San Mateo Caltrain Station and Santa Clara is 40.3 km. The road distance is 44 km.
You can take a vehicle from San Mateo Caltrain Station to El Camino & Scott via 2nd Ave & San Mateo Dr and Palo Alto Transit Center in around 2h 18m.