The average bus between San Sebastián de los Reyes and Santander takes 6h 3m and the fastest bus takes 5h 25m. The bus service runs several times per day from San Sebastián de los Reyes to Santander. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between San Sebastián de los Reyes and Santander. The earliest departure is at 10:24 AM in the morning, and the last departure from San Sebastián de los Reyes is at 10:24 PM which arrives into Santander at 6:30 AM. All services require a transfer at Av.Hispanidad-Aeropuerto T4 and take an average of 6h 3m. The schedules shown below are for the next available departures.

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5h 42m • 1 changeWant to know about travelling from San Sebastián de los Reyes to Santander? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Sebastián de los Reyes to Santander. However, there are services departing from Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) station and arriving at Estación de autobuses de Santander station via Estación de autobuses de Santander station. The journey, including transfers, takes approximately 6h 3m.
San Sebastián de los Reyes to Santander bus services, operated by ALSA, depart from Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) station.
San Sebastián de los Reyes to Santander bus services, operated by ALSA, arrive at Estación de autobuses de Santander station.
The distance between San Sebastián de los Reyes and Santander is 323.8 km. The road distance is 375 km.
ALSA operates a bus from Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) to Estación de autobuses de Santander every 4 hours. Tickets cost €30–55 and the journey takes 5h 15m.