The average bus between San Ysidro and La Mesa takes 2h 31m and the fastest bus takes 2h 4m. The bus runs at least 2 times per hour from San Ysidro to La Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 30 minutes between San Ysidro and La Mesa. The earliest departure is at 3:57 AM at night, and the last departure from San Ysidro is at 7:15 PM which arrives into La Mesa at 9:39 PM. All services require a transfer at Iris Avenue Transit Center and take an average of 2h 31m. The schedules shown below are for the next available departures.


2h 6m • 2 changes


2h 4m • 2 changes


2h 10m • 2 changes


2h 10m • 2 changes
Want to know about travelling from San Ysidro to La Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from San Ysidro to La Mesa. However, there are services departing from San Ysidro station and arriving at La Mesa station via 8th Street Transit Center. The journey, including transfers, takes approximately 2h 31m.
San Ysidro to La Mesa bus services, operated by San Diego Metro Transit, depart from Iris Avenue Transit Center station.
San Ysidro to La Mesa bus services, operated by San Diego Metro Transit, arrive at SDSU Transit Center station.
The distance between San Ysidro and La Mesa is 24.1 km. The road distance is 39 km.
You can take a bus from San Ysidro Bl & W Park Av to SDSU Transit Center via Iris Avenue Transit Center and 8th Street Transit Center in around 2h 24m.