The average bus between Santa Ana and La Jolla takes 4h 24m and the fastest bus takes 2h 36m. The bus service runs several times per day from Santa Ana to La Jolla. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santa Ana and La Jolla. The earliest departure is at 10:00 AM in the morning, and the last departure from Santa Ana is at 10:05 PM which arrives into La Jolla at 6:03 AM. All services require a transfer at San Diego Greyhound Bus Stop and take an average of 4h 24m. The schedules shown below are for the next available departures.

2h 36m • 1 change

2h 48m • 1 change
Arrives next day

7h 58m • 1 change

2h 36m • 1 change

2h 48m • 1 change
Arrives next day

7h 58m • 1 change

2h 36m • 1 change

2h 48m • 1 change
Arrives next day

7h 58m • 1 change

2h 36m • 1 change

2h 48m • 1 change
Arrives next day

8h 11m • 1 change

2h 54m • 1 change

2h 42m • 1 change
Arrives next day

8h 11m • 1 change
Want to know about travelling from Santa Ana to La Jolla? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Ana to La Jolla. However, there are services departing from Santa Ana station and arriving at La Jolla station via San Diego Greyhound Bus Stop. The journey, including transfers, takes approximately 4h 24m.
Santa Ana to La Jolla bus services, operated by Greyhound USA, depart from Santa Ana Bus Stop station.
Santa Ana to La Jolla bus services, operated by Greyhound USA, arrive at Silverado St & Herschel Av station.
Book your Santa Ana to La Jolla bus tickets online with Greyhound USA, San Diego Metro Transit and Flixbus USA.
The distance between Santa Ana and La Jolla is 114.1 km. The road distance is 157 km.
You can take a bus from Santa Ana Bus Stop to Silverado St & Herschel Av via San Diego Greyhound Bus Stop and Old Town Transit Center in around 2h 38m.