The average bus between Santa Ana and La Mesa takes 6h 8m and the fastest bus takes 3h 17m. The bus service runs several times per day from Santa Ana to La Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Santa Ana and La Mesa. The earliest departure is at 10:00 AM in the morning, and the last departure from Santa Ana is at 10:05 PM which arrives into La Mesa at 6:51 AM. All services require a transfer at San Diego Greyhound Bus Stop and take an average of 6h 8m. The schedules shown below are for the next available departures.
Want to know about travelling from Santa Ana to La Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Ana to La Mesa. However, there are services departing from Santa Ana station and arriving at La Mesa station via San Diego Greyhound Bus Stop. The journey, including transfers, takes approximately 6h 8m.
Santa Ana to La Mesa bus services, operated by Greyhound USA, depart from Santa Ana Bus Stop station.
Santa Ana to La Mesa bus services, operated by Greyhound USA, arrive at University Av & College Av station.
The distance between Santa Ana and La Mesa is 134.1 km. The road distance is 158 km.
You can take a bus from Santa Ana Bus Stop to University Av & Allison Av via San Diego Greyhound Bus Stop, Old Town Transit Center, and University Av & College Av in around 3h 24m.
