The average bus between Santa Ana and National City takes 2h 37m and the fastest bus takes 2h 19m. The bus service runs several times per day from Santa Ana to National City. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santa Ana and National City. The earliest departure is at 7:35 AM in the morning, and the last departure from Santa Ana is at 10:00 PM which arrives into National City at 5:00 AM. All services require a transfer at San Diego and take an average of 2h 37m. The schedules shown below are for the next available departures.

2h 28m • 1 change

2h 19m • 1 change
Arrives next day

2h 29m • 1 change

2h 28m • 1 change

2h 19m • 1 change
Arrives next day

2h 29m • 1 change

2h 28m • 1 change

2h 19m • 1 change
Arrives next day

2h 29m • 1 change

2h 34m • 1 change

2h 23m • 1 change
Arrives next day

2h 28m • 1 change
Want to know about travelling from Santa Ana to National City? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Ana to National City. However, there are services departing from Santa Ana station and arriving at National City station via San Diego. The journey, including transfers, takes approximately 2h 37m.
Santa Ana to National City bus services, operated by Greyhound Mexico, depart from Santa Ana station.
Santa Ana to National City bus services, operated by Greyhound Mexico, arrive at San Diego station.
The distance between Santa Ana and National City is 138.6 km. The road distance is 153 km.
Greyhound Mexico operates a bus from Santa Ana to San Diego 3 times a day. Tickets cost $18–28 and the journey takes 1h 45m.