The average bus between Santa Ana and Nogales takes 13h 37m and the fastest bus takes 11h 30m. The bus service runs several times per day from Santa Ana to Nogales. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Santa Ana and Nogales. The earliest departure is at 1:00 AM at night, and the last departure from Santa Ana is at 10:00 PM which arrives into Nogales at 7:30 AM. All services require a transfer, and take on average 13h 37m. The schedules shown below are for the next available departures.

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12h 15m • 1 changeWant to know about travelling from Santa Ana to Nogales? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Ana to Nogales. However, there are services departing from Santa Ana station and arriving at Nogales, AZ station via Huntington Park station. The journey, including transfers, takes approximately 13h 37m.
Santa Ana to Nogales bus services, operated by Limousine Express, depart from Santa Ana station.
Santa Ana to Nogales bus services, operated by Tufesa, arrive at Nogales, AZ station.
Book your Santa Ana to Nogales bus tickets online with Omio.
The distance between Santa Ana and Nogales is 703.4 km. The road distance is 861 km.
You can take a bus from Santa Ana to Nogales, AZ via Huntington Park in around 11h 32m.