Santa Ana to Otay Mesa Buses

Santa Ana to Otay Mesa buses

Travel from

Search accommodation with Expedia

Trip Overview

The average bus between Santa Ana and Otay Mesa takes 4h 14m and the fastest bus takes 3h 9m. The bus service runs several times per day from Santa Ana to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 14m
Duration: 118 mi
Distance: $33
Average price: Every 4 hours
Frequency

Bus

best

Take the bus from Santa Ana to San Ysidrobus Lxus 3105 / ...

2h 51m

$21–38

Santa Ana to Otay Mesa bus times

Buses run every 4 hours between Santa Ana and Otay Mesa. The earliest departure is at 5:55 AM in the morning, and the last departure from Santa Ana is at 10:05 PM which arrives into Otay Mesa at 5:03 AM. All services require a transfer at San Ysidro and take an average of 4h 14m. The schedules shown below are for the next available departures.

Departing Tuesday, October 20, 2026

2:35 PM → 6:19 PM
3h 44m • 2 changes
6:15 PM → 6:45 PM
3h 30m • 2 changes
8:25 PM → 8:47 PM
3h 22m • 2 changes
10:05 PM → 5:03 AM
Arrives next day
6h 58m • 2 changes

Departing Wednesday, October 21, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Thursday, October 22, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Friday, October 23, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Saturday, October 24, 2026

5:55 AM → 7:54 AM
4h 59m • 2 changes
9:10 AM → 10:54 AM
4h 44m • 2 changes
10:00 AM → 1:54 PM
3h 54m • 2 changes
2:35 PM → 5:54 PM
3h 19m • 2 changes
Show more

Departing Sunday, October 25, 2026

5:55 AM → 7:09 AM
4h 14m • 2 changes
9:10 AM → 10:09 AM
3h 59m • 2 changes
10:00 AM → 1:09 PM
3h 9m • 2 changes
2:35 PM → 6:09 PM
3h 34m • 2 changes
Show more

Departing Monday, October 26, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Santa Ana to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Santa Ana, CA, USA and Otay Mesa, CA, USA?

Limousine Express operates a bus from Santa Ana to San Ysidro 5 times a day. Tickets cost $30–45 and the journey takes 1h 50m. Two other operators also service this route.

Operators