Bus Santa Ana to Otay Mesa from $31 | Tickets & Timetables

Santa Ana to Otay Mesa buses

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Trip Overview

The average bus between Santa Ana and Otay Mesa takes 4h 14m and the fastest bus takes 3h 9m. The bus service runs several times per day from Santa Ana to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 14m
Duration: 118 mi
Distance: $31
Average price: Every 4 hours
Frequency

Bus

best

Take the bus from Santa Ana to San Ysidrobus Lxus 3105 / ...

2h 42m

$21–43

Santa Ana to Otay Mesa bus times

Buses run every 4 hours between Santa Ana and Otay Mesa. The earliest departure is at 5:55 AM in the morning, and the last departure from Santa Ana is at 10:05 PM which arrives into Otay Mesa at 5:03 AM. All services require a transfer at San Ysidro and take an average of 4h 14m. The schedules shown below are for the next available departures.

Departing Friday, August 14, 2026

5:55 AM → 6:54 AM
59 min • 2 changes
9:10 AM → 10:19 AM
1h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
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Departing Saturday, August 15, 2026

5:55 AM → 7:54 AM
1h 59m • 2 changes
9:10 AM → 10:54 AM
1h 44m • 2 changes
10:00 AM → 1:54 PM
3h 54m • 2 changes
2:35 PM → 5:54 PM
3h 19m • 2 changes
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Departing Sunday, August 16, 2026

5:55 AM → 7:09 AM
1h 14m • 2 changes
9:10 AM → 10:09 AM
59 min • 2 changes
10:00 AM → 1:09 PM
3h 9m • 2 changes
2:35 PM → 6:09 PM
3h 34m • 2 changes
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Departing Monday, August 17, 2026

5:55 AM → 6:54 AM
59 min • 2 changes
9:10 AM → 10:19 AM
1h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Tuesday, August 18, 2026

5:55 AM → 6:54 AM
59 min • 2 changes
9:10 AM → 10:19 AM
1h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Wednesday, August 19, 2026

5:55 AM → 6:54 AM
59 min • 2 changes
9:10 AM → 10:19 AM
1h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Thursday, August 20, 2026

5:55 AM → 6:54 AM
59 min • 2 changes
9:10 AM → 10:19 AM
1h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Santa Ana to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.