Rome2Rio

Santa Ana to San Francisco buses

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Trip Overview

The average bus between Santa Ana and San Francisco takes 12h 40m and the fastest bus takes 9h 22m. There is at least one bus per day from Santa Ana to San Francisco. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 40m
Duration
426 mi
Distance
$82
Average price
Once daily
Frequency

Santa Ana to San Francisco bus times

Buses run once daily between Santa Ana and San Francisco. The earliest departure is at 12:07 AM at night, and the last departure from Santa Ana is at 11:07 PM which arrives into San Francisco at 8:30 AM. All services require a transfer at Artic - Dock 4 and take an average of 12h 40m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    OCTAFlixbus USA9h 24m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    OCTAFlixbus USA9h 24m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    OCTAFlixbus USA9h 24m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    OCTAFlixbus USA9h 22m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    OCTAFlixbus USA32h 22m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    OCTAFlixbus USA9h 24m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    OCTAFlixbus USA9h 24m • 1 change

Frequently asked questions

Want to know about travelling from Santa Ana to San Francisco? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santa Ana to San Francisco.ExpandLaunch map view
  • Distance: 426.4 mi
  • Duration: 12h 40m

What companies run services between Santa Ana, CA, USA and San Francisco, CA, USA?

Flixbus USA operates a bus from Anaheim Regional Transportation Intermodal Center to San Francisco once daily. Tickets cost $65–100 and the journey takes 8h 15m.

Operators