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Santa Ana to San Ysidro buses

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Trip Overview

The average bus between Santa Ana and San Ysidro takes 3h 13m and the fastest bus takes 2h 1m. The bus service runs several times per day from Santa Ana to San Ysidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 13m
Duration
111 mi
Distance
$25
Average price
Every 3 hours
Frequency

Bus via San Ysidro Transit Center

best
  1. Take the bus from Santa Ana to San Ysidrobus bus Lxus 3105 / ...
2h 7m
$18–32

Santa Ana to San Ysidro bus times

Buses run every 3 hours between Santa Ana and San Ysidro. The earliest departure is at 5:55 AM in the morning, and the last departure from Santa Ana is at 11:10 PM which arrives into San Ysidro at 10:11 PM. All services require a transfer at San Ysidro Transit Center and take an average of 3h 13m. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

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    Arrives next day

    Greyhound USASan Diego Metro Transit6h 6m • 1 change

Departing Saturday, October 10, 2026

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    Limousine ExpressSan Diego Metro Transit3h 39m • 1 change

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    Limousine ExpressSan Diego Metro Transit3h 27m • 1 change

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    Greyhound USASan Diego Metro Transit2h 41m • 1 change

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    Flixbus USASan Diego Metro Transit2h 51m • 1 change
  • Show more

Departing Sunday, October 11, 2026

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    Limousine ExpressSan Diego Metro Transit3h 39m • 1 change

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    Limousine ExpressSan Diego Metro Transit3h 27m • 1 change

  •  → 

    Greyhound USASan Diego Metro Transit2h 41m • 1 change

  •  → 

    Flixbus USASan Diego Metro Transit2h 51m • 1 change
  • Show more

Departing Monday, October 12, 2026

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    Limousine ExpressSan Diego Metro Transit3h 26m • 1 change

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    Limousine ExpressSan Diego Metro Transit3h 16m • 1 change

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    Greyhound USASan Diego Metro Transit2h 43m • 1 change

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    Flixbus USASan Diego Metro Transit2h 55m • 1 change
  • Show more

Departing Tuesday, October 13, 2026

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    Limousine ExpressSan Diego Metro Transit3h 26m • 1 change

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    Limousine ExpressSan Diego Metro Transit3h 16m • 1 change

  •  → 

    Greyhound USASan Diego Metro Transit2h 43m • 1 change

  •  → 

    Flixbus USASan Diego Metro Transit2h 55m • 1 change
  • Show more

Departing Wednesday, October 14, 2026

  •  → 

    Limousine ExpressSan Diego Metro Transit3h 26m • 1 change

  •  → 

    Limousine ExpressSan Diego Metro Transit3h 16m • 1 change

  •  → 

    Greyhound USASan Diego Metro Transit2h 43m • 1 change

  •  → 

    Flixbus USASan Diego Metro Transit2h 55m • 1 change
  • Show more

Departing Thursday, October 15, 2026

  •  → 

    Limousine ExpressSan Diego Metro Transit3h 26m • 1 change

  •  → 

    Limousine ExpressSan Diego Metro Transit3h 16m • 1 change

  •  → 

    Greyhound USASan Diego Metro Transit2h 43m • 1 change

  •  → 

    Flixbus USASan Diego Metro Transit2h 55m • 1 change
  • Show more

Frequently asked questions

Want to know about travelling from Santa Ana to San Ysidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santa Ana to San Ysidro.ExpandLaunch map view
  • Distance: 110.6 mi
  • Duration: 3h 13m

What companies run services between Santa Ana, CA, USA and San Ysidro, CA, USA?

Limousine Express operates a bus from Santa Ana to San Ysidro 5 times a day. Tickets cost $30–45 and the journey takes 1h 50m. Two other operators also service this route.

Operators