The average bus between Santa Clara and Mission Viejo takes 14h 13m and the fastest bus takes 11h 9m. The bus service runs several times per day from Santa Clara to Mission Viejo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santa Clara and Mission Viejo. The earliest departure is at 5:30 AM in the morning, and the last departure from Santa Clara is at 11:54 AM which arrives into Mission Viejo at 5:50 AM. All services require a transfer at San Jose Diridon Caltrain Southbound and take an average of 14h 13m. The schedules shown below are for the next available departures.



11h 49m • 3 changes
Arrives next day



13h 24m • 3 changes
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17h 25m • 3 changes



11h 49m • 3 changes
Arrives next day



13h 24m • 3 changes
Arrives next day



17h 25m • 3 changes



11h 49m • 3 changes
Arrives next day



13h 24m • 3 changes
Arrives next day



17h 25m • 3 changes



11h 49m • 3 changes
Arrives next day



13h 24m • 3 changes
Arrives next day



17h 25m • 3 changes
Want to know about travelling from Santa Clara to Mission Viejo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Clara to Mission Viejo. However, there are services departing from Santa Clara station and arriving at Mission Viejo station via Anaheim Regional Transportation Intermodal Center. The journey, including transfers, takes approximately 14h 13m.
Santa Clara to Mission Viejo bus services, operated by Santa Clara VTA, depart from San Jose Diridon Station.
Santa Clara to Mission Viejo bus services, operated by Santa Clara VTA, arrive at Anaheim Regional Transportation Intermodal Center station.
The distance between Santa Clara and Mission Viejo is 569.7 km. The road distance is 659 km.
Greyhound USA operates a bus from San Jose Diridon Station to Anaheim Regional Transportation Intermodal Center once daily. Tickets cost $55–110 and the journey takes 9h.