The average bus between Santa Clara and Santa Ana takes 14h 2m and the fastest bus takes 10h 41m. The bus service runs several times per day from Santa Clara to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santa Clara and Santa Ana. The earliest departure is at 5:30 AM in the morning, and the last departure from Santa Clara is at 11:54 AM which arrives into Santa Ana at 5:25 AM. All services require a transfer at San Jose Diridon Caltrain Southbound and take an average of 14h 2m. The schedules shown below are for the next available departures.



11h 18m • 3 changes



12h 58m • 3 changes
Arrives next day



16h 56m • 3 changes



11h 18m • 3 changes



12h 58m • 3 changes
Arrives next day



16h 56m • 3 changes
Want to know about travelling from Santa Clara to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Clara to Santa Ana. However, there are services departing from Santa Clara station and arriving at Santa Ana station via Santa Ana Bus Stop. The journey, including transfers, takes approximately 14h 2m.
Santa Clara to Santa Ana bus services, operated by Santa Clara VTA, depart from San Jose Diridon Station.
Santa Clara to Santa Ana bus services, operated by Santa Clara VTA, arrive at Santa Ana Bus Stop station.
Book your Santa Clara to Santa Ana bus tickets online with Santa Clara VTA, Tufesa and 2 other operators.
The distance between Santa Clara and Santa Ana is 545.5 km. The road distance is 629 km.
Greyhound USA operates a bus from San Jose Diridon Station to Santa Ana Bus Stop once daily. Tickets cost $55–120 and the journey takes 9h 25m.