The average bus between Santa Fe and Madrid takes 6h 26m and the fastest bus takes 5h 5m. The bus service runs several times per day from Santa Fe to Madrid. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Santa Fe and Madrid. The earliest departure is at 8:10 AM in the morning, and the last departure from Santa Fe is at 7:50 PM which arrives into Madrid at 5:30 AM. All services require a transfer, and take on average 6h 26m. The schedules shown below are for the next available departures.

5h 5m • 1 change

5h 20m • 1 change

6h 5m • 1 change

6h 20m • 1 change

5h 5m • 1 change

5h 20m • 1 change

7h 5m • 1 change

6h 20m • 1 change

5h 5m • 1 change

5h 20m • 1 change

7h 5m • 1 change

6h 20m • 1 change

5h 5m • 1 change

5h 20m • 1 change

7h 5m • 1 change

6h 20m • 1 change

5h 5m • 1 change

5h 20m • 1 change

7h 5m • 1 change

6h 20m • 1 change

5h 20m • 1 change

5h 35m • 1 change

7h 35m • 1 change

5h 20m • 1 change
Want to know about travelling from Santa Fe to Madrid? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Fe to Madrid. However, there are services departing from Santa Fe station and arriving at Madrid station via Estación Sur de Autobuses. The journey, including transfers, takes approximately 6h 26m.
Santa Fe to Madrid bus services, operated by ALSA, depart from Granada Estación de Autobuses station.
Santa Fe to Madrid bus services, operated by ALSA, arrive at Estación Sur de Autobuses station.
The distance between Santa Fe and Madrid is 358.9 km. The road distance is 421 km.
ALSA operates a bus from Granada Estación de Autobuses to Estación Sur de Autobuses every 3 hours. Tickets cost €30–50 and the journey takes 5h.