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Santa Fe Depot to Irvine buses

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Trip Overview

The bus between Santa Fe Depot and Irvine takes 8h 32m. The bus runs, on average, 5 times per week from Santa Fe Depot to Irvine. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 32m
Duration
87 mi
Distance
5 times a week
Frequency

Santa Fe Depot to Irvine bus times

Buses run 5 times a week between Santa Fe Depot and Irvine. The service departs Santa Fe Depot at 10:10 PM at night, which arrives into Irvine at 06:42:00. All services require a transfer at Irvine Station-Dock 5 and take an average of 8h 32m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    AmtrakOCTA8h 32m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    AmtrakOCTA8h 32m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    AmtrakOCTA8h 32m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    AmtrakOCTA8h 32m • 1 change

Frequently asked questions

Want to know about travelling from Santa Fe Depot to Irvine? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santa Fe Depot to Irvine.ExpandLaunch map view
  • Distance: 86.5 mi
  • Duration: 8h 32m

What companies run services between Santa Fe Depot, San Diego County, CA, USA and Irvine, CA, USA?

Amtrak operates a bus from San Diego to Irvine once daily, and the journey takes 1h 45m.

Operators