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Santa Maria Novella to Palermo buses

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Trip Overview

The average bus between Santa Maria Novella and Palermo takes 17h 32m and the fastest bus takes 17h 30m. There is at least one bus per day from Santa Maria Novella to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 32m
Duration
1,278 km
Distance
€135
Average price
Once daily
Frequency

Santa Maria Novella to Palermo bus times

Buses run once daily between Santa Maria Novella and Palermo. The earliest departure is at 5:20 PM in the evening, and the last departure from Santa Maria Novella is at 5:30 PM which arrives into Palermo at 11:00 AM. All services require a transfer at Firenze Autostazione and take an average of 17h 32m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

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    Arrives next day

    Autolinee ToscaneFlixBus17h 30m • 1 change

Departing Saturday, November 7, 2026

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    Arrives next day

    Autolinee ToscaneFlixBus17h 40m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Autolinee ToscaneFlixBus17h 40m • 1 change

Departing Monday, November 9, 2026

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    Arrives next day

    Autolinee ToscaneFlixBus17h 30m • 1 change

Departing Tuesday, November 10, 2026

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    Arrives next day

    Autolinee ToscaneFlixBus17h 30m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    Autolinee ToscaneFlixBus17h 30m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Autolinee ToscaneFlixBus17h 30m • 1 change

Frequently asked questions

Want to know about travelling from Santa Maria Novella to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santa Maria Novella to Palermo.ExpandLaunch map view
  • Distance: 1,277.5 km
  • Duration: 17h 32m

What companies run services between Santa Maria Novella, Italy and Palermo, Italy?

You can take a vehicle from Santa Maria Novella to Palermo via Firenze Autostazione, P.Camollia, and Siena in around 18h 28m.

Operators