Rome2Rio

Santa Maria Novella to Rome buses

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Trip Overview

The average bus between Santa Maria Novella and Rome takes 3h 19m and the fastest bus takes 3h. There is at least one bus per day from Santa Maria Novella to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 19m
Duration
275 km
Distance
€25
Average price
Once daily
Frequency

Santa Maria Novella to Rome bus times

Buses run once daily between Santa Maria Novella and Rome. The earliest departure is at 2:30 AM at night, and the last departure from Santa Maria Novella is at 2:45 AM which arrives into Rome at 6:10 AM. All services run direct with no transfers required, and take on average 3h 19m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    bus bus 3h 25m • Direct

Departing Thursday, November 12, 2026

  •  → 

    bus bus 3h 25m • Direct

Departing Friday, November 13, 2026

  •  → 

    bus bus 3h 25m • Direct

Departing Saturday, November 14, 2026

  •  → 

    bus bus 3h 25m • Direct

Departing Sunday, November 15, 2026

  •  → 

    bus bus 3h 25m • Direct

Departing Monday, November 16, 2026

  •  → 

    bus bus 3h 25m • Direct

Departing Tuesday, November 17, 2026

  •  → 

    bus bus 3h • Direct

Frequently asked questions

Want to know about travelling from Santa Maria Novella to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santa Maria Novella to Rome.ExpandLaunch map view
  • Distance: 275.3 km
  • Duration: 3h 19m

What companies run services between Santa Maria Novella, Italy and Rome, Italy?

FlixBus operates a bus from Florence to Roma, Autostazione Tiburtina once daily. Tickets cost €24–40 and the journey takes 3h 25m. TTI Leonettibus SRL also services this route once a week.

Operators