The bus between Santa Maria and Los Osos takes 2h 3m. The bus runs, on average, 6 times per week from Santa Maria to Los Osos. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 6 times a week between Santa Maria and Los Osos. The earliest departure is at 7:10 AM in the morning, and the last departure from Santa Maria is at 6:10 PM which arrives into Los Osos at 8:13 PM. All services require a transfer, and take on average 2h 3m. The schedules shown below are for the next available departures.

2h 3m • 1 change

2h 3m • 1 change

2h 3m • 1 change

2h 3m • 1 change
Want to know about travelling from Santa Maria to Los Osos? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Maria to Los Osos. However, there are services departing from Santa Maria station and arriving at Los Osos station via Government Center. The journey, including transfers, takes approximately 2h 3m.
Santa Maria to Los Osos bus services, operated by San Luis Obispo RTA, depart from Santa Maria Transit Center station.
Santa Maria to Los Osos bus services, operated by San Luis Obispo RTA, arrive at 10th & Los Osos Valley station.
The distance between Santa Maria and Los Osos is 53.7 km. The road distance is 90 km.
You can take a bus from Santa Maria Transit Center to 10th & Los Osos Valley via Government Center in around 2h 58m.