The average bus between Santander and Alcalá de Henares takes 6h 22m and the fastest bus takes 5h 54m. The bus service runs several times per day from Santander to Alcalá de Henares. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Santander and Alcalá de Henares. The earliest departure is at 1:00 AM at night, and the last departure from Santander is at 3:30 PM which arrives into Alcalá de Henares at 9:24 PM. All services require a transfer, and take on average 6h 22m. The schedules shown below are for the next available departures.

6h 39m • 1 change

6h 29m • 1 change

6h 24m • 1 change

5h 54m • 1 change

6h 39m • 1 change

6h 29m • 1 change

6h 24m • 1 change

5h 54m • 1 change

6h 39m • 1 change

6h 29m • 1 change

6h 24m • 1 change

5h 54m • 1 change

6h 39m • 1 change

6h 29m • 1 change

6h 24m • 1 change

5h 54m • 1 change
Want to know about travelling from Santander to Alcalá de Henares? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santander to Alcalá de Henares. However, there are services departing from Santander station and arriving at Alcalá de Henares station via Madrid, Avenida de América. The journey, including transfers, takes approximately 6h 22m.
Santander to Alcalá de Henares bus services, operated by ALSA, depart from Estación de autobuses de Santander station.
Santander to Alcalá de Henares bus services, operated by ALSA, arrive at Madrid, Avenida de América station.
The distance between Santander and Alcalá de Henares is 333.7 km. The road distance is 437 km.
ALSA operates a bus from Estación de autobuses de Santander to Madrid, Avenida de América every 4 hours. Tickets cost €30–50 and the journey takes 5h 30m.