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Santander to Brindisi buses

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Trip Overview

The bus between Santander and Brindisi takes 37h 45m. The bus runs, on average, 2 times per week from Santander to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

37h 45m
Duration
2,491 km
Distance
€260
Average price
Twice a week
Frequency

Santander to Brindisi bus times

Buses run twice a week between Santander and Brindisi. The service departs Santander at 8:20 PM in the evening, which arrives into Brindisi at 10:05:00. All services require a transfer at Bilbao Intermodal and take an average of 37h 45m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    ALSAFlixBusFlixBus37h 45m • 2 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    ALSAFlixBusFlixBus37h 45m • 2 changes

Frequently asked questions

Want to know about travelling from Santander to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santander to Brindisi.ExpandLaunch map view
  • Distance: 2,491.1 km
  • Duration: 37h 45m

What companies run services between Santander, Spain and Brindisi, Italy?

You can take a bus from Estación de autobuses de Santander to Brindisi via Bilbao Intermodal, Bilbao, and Grenoble in around 35h 55m.

Operators