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Santander to Brindisi buses

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Trip Overview

The average bus between Santander and Brindisi takes 42h 21m and the fastest bus takes 37h 45m. The bus runs, on average, 5 times per week from Santander to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h 21m
Duration
2,482 km
Distance
€240
Average price
5 times a week
Frequency

Santander to Brindisi bus times

Buses run 5 times a week between Santander and Brindisi. The earliest departure is at 12:30 PM in the afternoon, and the last departure from Santander is at 8:20 PM which arrives into Brindisi at 10:05 AM. All services require a transfer at Bilbao Intermodal and take an average of 42h 21m. The schedules shown below are for the next available departures.

Departing Friday, October 16, 2026

  •  → 

    Arrives +2 days

    ALSAFlixBusFlixBus45h 35m • 2 changes

Departing Saturday, October 17, 2026

  •  → 

    Arrives +2 days

    ALSAFlixBusFlixBus37h 45m • 2 changes

Departing Sunday, October 18, 2026

  •  → 

    Arrives +2 days

    ALSAFlixBusFlixBus45h 5m • 2 changes

Departing Monday, October 19, 2026

  •  → 

    Arrives +2 days

    ALSAFlixBusFlixBus45h 35m • 2 changes

Departing Tuesday, October 20, 2026

  •  → 

    Arrives +2 days

    ALSAFlixBusFlixBus37h 45m • 2 changes

Frequently asked questions

Want to know about travelling from Santander to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santander to Brindisi.ExpandLaunch map view
  • Distance: 2,482.4 km
  • Duration: 42h 21m

What companies run services between Santander, Spain and Brindisi, Italy?

You can take a bus from Estación de autobuses de Santander to Brindisi via Bilbao Intermodal, Bilbao, and Grenoble in around 37h 35m.

Operators