The average bus between Santander and Castille and León takes 4h 18m and the fastest bus takes 3h 34m. The bus service runs several times per day from Santander to Castille and León. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santander and Castille and León. The earliest departure is at 9:00 AM in the morning, and the last departure from Santander is at 9:00 PM which arrives into Castille and León at 7:30 AM. All services require a transfer at Valladolid and take an average of 4h 18m. The schedules shown below are for the next available departures.

3h 34m • 1 change

4h 2m • 1 change

3h 34m • 1 change
Arrives next day

7h 1m • 1 change

3h 34m • 1 change

4h 2m • 1 change
Arrives next day

6h 1m • 1 change
Want to know about travelling from Santander to Castille and León? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santander to Castille and León. However, there are services departing from Santander station and arriving at Castille and León station via Valladolid. The journey, including transfers, takes approximately 4h 18m.
Santander to Castille and León bus services, operated by ALSA, depart from Estación de autobuses de Santander station.
Santander to Castille and León bus services, operated by ALSA, arrive at Valladolid station.
The distance between Santander and Castille and León is 200.1 km. The road distance is 252 km.
ALSA operates a bus from Estación de autobuses de Santander to Valladolid twice daily. Tickets cost €21–30 and the journey takes 3h 15m.