The average bus between Santander and Guadalajara takes 6h 44m and the fastest bus takes 6h 25m. The bus service runs several times per day from Santander to Guadalajara. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Santander and Guadalajara. The earliest departure is at 1:00 AM at night, and the last departure from Santander is at 5:30 PM which arrives into Guadalajara at 12:25 AM. All services require a transfer, and take on average 6h 44m. The schedules shown below are for the next available departures.

6h 40m • 1 change

6h 45m • 1 change

6h 55m • 1 change

6h 25m • 1 change

6h 40m • 1 change

6h 45m • 1 change

6h 55m • 1 change

6h 25m • 1 change

6h 40m • 1 change

6h 45m • 1 change

6h 55m • 1 change

6h 25m • 1 change

6h 40m • 1 change

6h 45m • 1 change

6h 55m • 1 change

6h 25m • 1 change

6h 40m • 1 change

6h 45m • 1 change

6h 55m • 1 change

6h 25m • 1 change

6h 40m • 1 change

6h 45m • 1 change

6h 55m • 1 change

6h 25m • 1 change
Want to know about travelling from Santander to Guadalajara? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santander to Guadalajara. However, there are services departing from Santander station and arriving at Guadalajara station via Madrid, Avenida de América. The journey, including transfers, takes approximately 6h 44m.
Santander to Guadalajara bus services, operated by ALSA, depart from Estación de autobuses de Santander station.
Santander to Guadalajara bus services, operated by ALSA, arrive at Guadalajara station.
Book your Santander to Guadalajara bus tickets online with ALSA.
The distance between Santander and Guadalajara is 319.8 km. The road distance is 460 km.
You can take a bus from Estación de autobuses de Santander to Guadalajara via Madrid, Avenida de América in around 7h 4m.