The average bus between Santander and Madrid Atocha Station takes 6h 7m and the fastest bus takes 5h 42m. The bus service runs several times per day from Santander to Madrid Atocha Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Santander and Madrid Atocha Station. The earliest departure is at 1:00 AM at night, and the last departure from Santander is at 5:30 PM which arrives into Madrid Atocha Station at 11:30 PM. All services require a transfer at Madrid, Avenida de América and take an average of 6h 7m. The schedules shown below are for the next available departures.

5h 57m • 1 change

6h 23m • 1 change

6h 20m • 1 change

5h 51m • 1 change

5h 57m • 1 change

6h 23m • 1 change

6h 20m • 1 change

5h 51m • 1 change

5h 57m • 1 change

6h 23m • 1 change

6h 20m • 1 change

5h 51m • 1 change

5h 57m • 1 change

6h 23m • 1 change

6h 20m • 1 change

5h 51m • 1 change

6h 30m • 1 change

6h 28m • 1 change

6h 19m • 1 change

5h 42m • 1 change
Want to know about travelling from Santander to Madrid Atocha Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santander to Madrid Atocha Station. However, there are services departing from Santander station and arriving at Madrid Atocha Station station via Madrid, Avenida de América. The journey, including transfers, takes approximately 6h 7m.
Santander to Madrid Atocha Station bus services, operated by ALSA, depart from Estación de autobuses de Santander station.
Santander to Madrid Atocha Station bus services, operated by ALSA, arrive at Madrid, Avenida de América station.
The distance between Santander and Madrid Atocha Station is 340.5 km. The road distance is 415 km.
ALSA operates a bus from Estación de autobuses de Santander to Madrid, Avenida de América every 4 hours. Tickets cost €30–50 and the journey takes 5h 30m.