Rome2Rio

Santander to Madrid buses

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Trip Overview

The average bus between Santander and Madrid takes 6h 23m and the fastest bus takes 6h 19m. The bus runs, on average, 5 times per week from Santander to Madrid. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 23m
Duration
412 km
Distance
€43
Average price
5 times a week
Frequency

Santander to Madrid bus times

Buses run 5 times a week between Santander and Madrid. The service departs Santander at 5:30 PM in the evening, which arrives into Madrid at 23:54:41. All services require a transfer at Madrid, Avenida de América and take an average of 6h 23m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    ALSAEmpresa Municipal de Transportes6h 24m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    ALSAEmpresa Municipal de Transportes6h 24m • 1 change

Departing Friday, November 13, 2026

  •  → 

    ALSAEmpresa Municipal de Transportes6h 19m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    ALSAEmpresa Municipal de Transportes6h 24m • 1 change

Departing Monday, November 16, 2026

  •  → 

    ALSAEmpresa Municipal de Transportes6h 24m • 1 change

Frequently asked questions

Want to know about travelling from Santander to Madrid? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santander to Madrid.ExpandLaunch map view
  • Distance: 412 km
  • Duration: 6h 23m

What companies run services between Santander, Spain and Madrid, Spain?

ALSA operates a bus from Estación de autobuses de Santander to Madrid, Avenida de América every 4 hours. Tickets cost €30–55 and the journey takes 5h 30m.

Operators