The average bus between Santander and Madrid (Station) takes 5h 50m and the fastest bus takes 5h 29m. The bus service runs several times per day from Santander to Madrid (Station). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Santander and Madrid (Station). The earliest departure is at 1:00 AM at night, and the last departure from Santander is at 5:30 PM which arrives into Madrid (Station) at 11:22 PM. All services require a transfer, and take on average 5h 50m. The schedules shown below are for the next available departures.

5h 44m • 1 change
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5h 34m • 1 change
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6h 1m • 1 change
5h 29m • 1 change
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6h 1m • 1 change
6h 4m • 1 change
5h 29m • 1 change
5h 42m • 1 change
6h 1m • 1 change
6h 4m • 1 change
5h 29m • 1 change
5h 42m • 1 change
6h 1m • 1 change
6h 4m • 1 change
5h 29m • 1 change
5h 42m • 1 change
6h 1m • 1 change
6h 4m • 1 change
5h 29m • 1 changeWant to know about travelling from Santander to Madrid (Station)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santander to Madrid (Station). However, there are services departing from Santander station and arriving at Madrid (Station) station via Madrid, Avenida de América. The journey, including transfers, takes approximately 5h 50m.
Santander to Madrid (Station) bus services, operated by ALSA, depart from Estación de autobuses de Santander station.
Santander to Madrid (Station) bus services, operated by ALSA, arrive at Madrid, Avenida de América station.
The distance between Santander and Madrid (Station) is 335.7 km. The road distance is 410 km.
ALSA operates a bus from Estación de autobuses de Santander to Madrid, Avenida de América every 4 hours. Tickets cost €30–55 and the journey takes 5h 30m.