The average bus between Santander and Murcia takes 12h 8m and the fastest bus takes 11h 15m. The bus service runs several times per day from Santander to Murcia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santander and Murcia. The earliest departure is at 1:00 AM at night, and the last departure from Santander is at 3:30 PM which arrives into Murcia at 4:35 AM. All services require a transfer, and take on average 12h 8m. The schedules shown below are for the next available departures.

12h 5m • 1 change

11h 15m • 1 change
Arrives next day

13h 5m • 1 change

12h 5m • 1 change

11h 15m • 1 change
Arrives next day

13h 5m • 1 change

12h 5m • 1 change

11h 15m • 1 change
Arrives next day

13h 5m • 1 change

12h 5m • 1 change

11h 15m • 1 change
Arrives next day

13h 5m • 1 change
Want to know about travelling from Santander to Murcia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santander to Murcia. However, there are services departing from Santander station and arriving at Murcia station via Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid). The journey, including transfers, takes approximately 12h 8m.
Santander to Murcia bus services, operated by ALSA, depart from Estación de autobuses de Santander station.
Santander to Murcia bus services, operated by ALSA, arrive at Estación de Autobuses de Murcia station.
Book your Santander to Murcia bus tickets online with ALSA.
The distance between Santander and Murcia is 649.3 km. The road distance is 810 km.
You can take a bus from Estación de autobuses de Santander to Estación de Autobuses de Murcia via Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) in around 11h 35m.