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Santander to Palermo buses

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Trip Overview

The bus between Santander and Palermo takes 2d 16h. The bus runs, on average, 2 times per week from Santander to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 16h
Duration
2,985 km
Distance
€316
Average price
Twice a week
Frequency

Santander to Palermo bus times

Buses run twice a week between Santander and Palermo. The service departs Santander at 5:50 PM in the evening, which arrives into Palermo at 11:00:00. All services require a transfer at Bordeaux and take an average of 2d 16h. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives +3 days

    FlixBusFlixBusFlixBus2d 16h • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +3 days

    FlixBusFlixBusFlixBus2d 16h • 2 changes

Frequently asked questions

Want to know about travelling from Santander to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santander to Palermo.ExpandLaunch map view
  • Distance: 2,984.8 km
  • Duration: 2d 16h

What companies run services between Santander, Spain and Palermo, Italy?

You can take a bus from Estación de autobuses de Santander to Palermo via Bordeaux and Florence Villa Constanza Bus Station in around 42h 15m.

Operators