Rome2Rio

Santander to Rome buses

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Trip Overview

The bus between Santander and Rome takes 46h 35m. The bus runs, on average, 2 times per week from Santander to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

46h 35m
Duration
1,987 km
Distance
€201
Average price
Twice a week
Frequency

Santander to Rome bus times

Buses run twice a week between Santander and Rome. The service departs Santander at 5:50 PM in the evening, which arrives into Rome at 17:25:00. All services require a transfer at Bordeaux and take an average of 46h 35m. The schedules shown below are for the next available departures.

Departing Sunday, November 1, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus46h 35m • 2 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus46h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Santander to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santander to Rome.ExpandLaunch map view
  • Distance: 1,987.1 km
  • Duration: 46h 35m

What companies run services between Santander, Spain and Rome, Italy?

You can take a bus from Estación de autobuses de Santander to Roma, Autostazione Tiburtina via Bordeaux and Florence Villa Constanza Bus Station in around 27h 57m.

Operators