The average bus between Santarém and Ayamonte takes 6h 13m and the fastest bus takes 5h 55m. The bus service runs several times per day from Santarém to Ayamonte. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santarém and Ayamonte. The earliest departure is at 8:45 AM in the morning, and the last departure from Santarém is at 7:00 PM which arrives into Ayamonte at 12:55 AM. All services require a transfer, and take on average 6h 13m. The schedules shown below are for the next available departures.

6h 10m • 1 change

6h 40m • 1 change
Arrives next day

5h 55m • 1 change

6h 10m • 1 change

6h 40m • 1 change
Arrives next day

5h 55m • 1 change
Want to know about travelling from Santarém to Ayamonte? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santarém to Ayamonte. However, there are services departing from Santarém station and arriving at Ayamonte station via Estação Rodoviária de Sete Rios. The journey, including transfers, takes approximately 6h 13m.
Santarém to Ayamonte bus services, operated by Rede Expressos, depart from Terminal Rodoviário de Santarém station.
Santarém to Ayamonte bus services, operated by Rede Expressos, arrive at Terminal Rodoviário de Vila Real de Santo António station.
Book your Santarém to Ayamonte bus tickets online with Rede Expressos.
The distance between Santarém and Ayamonte is 250.7 km. The road distance is 415 km.
You can take a bus from Terminal Rodoviário de Santarém to Terminal Rodoviário de Vila Real de Santo António via Estação Rodoviária de Sete Rios in around 6h 11m.