The average bus between Santee and Otay Mesa takes 3h 5m and the fastest bus takes 2h 35m. There is a bus service every few hours from Santee to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Santee and Otay Mesa. The earliest departure is at 6:25 AM in the morning, and the last departure from Santee is at 9:27 PM which arrives into Otay Mesa at 4:26 AM. All services require a transfer at College Av & SDSU Transit Center and take an average of 3h 5m. The schedules shown below are for the next available departures.



2h 49m • 3 changes



2h 49m • 3 changes



2h 43m • 3 changes



2h 35m • 3 changes



2h 50m • 3 changes



2h 51m • 3 changes



2h 49m • 3 changes



2h 49m • 3 changes



2h 50m • 3 changes



2h 51m • 3 changes



2h 49m • 3 changes



2h 49m • 3 changes
Want to know about travelling from Santee to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santee to Otay Mesa. However, there are services departing from Santee station and arriving at Otay Mesa station via Park Bl & Broadway. The journey, including transfers, takes approximately 3h 5m.
Santee to Otay Mesa bus services, operated by San Diego Metro Transit, depart from SDSU Transit Center station.
Santee to Otay Mesa bus services, operated by San Diego Metro Transit, arrive at Otay Mesa Transit Center station.
The distance between Santee and Otay Mesa is 30.7 km. The road distance is 73 km.
You can take a bus from Grossmont College to Otay Mesa Rd & Cactus Rd via College Av & SDSU Transit Center, SDSU Transit Center, Broadway & Park Bl, and Otay Mesa Transit Center in around 3h 1m.