The average bus between Santillana del Mar and Madrid takes 6h 55m and the fastest bus takes 5h 30m. The bus service runs several times per day from Santillana del Mar to Madrid. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Santillana del Mar and Madrid. The earliest departure is at 11:30 AM in the morning, and the last departure from Santillana del Mar is at 9:15 PM which arrives into Madrid at 6:30 AM. All services require a transfer, and take on average 6h 55m. The schedules shown below are for the next available departures.

6h 15m • 1 change

5h 30m • 1 change

6h 30m • 1 change
Arrives next day

9h 15m • 1 change

6h 15m • 1 change

5h 30m • 1 change

6h 30m • 1 change
Arrives next day

9h 15m • 1 change

6h • 1 change

8h • 1 change

5h 45m • 1 change
Arrives next day

9h 30m • 1 change

6h • 1 change

8h • 1 change

5h 45m • 1 change
Arrives next day

9h 30m • 1 change
Want to know about travelling from Santillana del Mar to Madrid? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santillana del Mar to Madrid. However, there are services departing from Santillana del Mar station and arriving at Madrid station via Madrid, Avenida de América. The journey, including transfers, takes approximately 6h 55m.
Santillana del Mar to Madrid bus services, operated by ALSA, depart from Torrelavega station.
Santillana del Mar to Madrid bus services, operated by ALSA, arrive at Madrid, Avenida de América station.
The distance between Santillana del Mar and Madrid is 332.4 km. The road distance is 391 km.
ALSA operates a bus from Torrelavega to Madrid, Avenida de América every 4 hours. Tickets cost €30–50 and the journey takes 5h 10m.