The average bus between Santillana del Mar and San Sebastián de los Reyes takes 7h 19m and the fastest bus takes 5h 42m. The bus service runs several times per day from Santillana del Mar to San Sebastián de los Reyes. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santillana del Mar and San Sebastián de los Reyes. The earliest departure is at 11:30 AM in the morning, and the last departure from Santillana del Mar is at 9:15 PM which arrives into San Sebastián de los Reyes at 6:55 AM. All services require a transfer at Torrelavega and take an average of 7h 19m. The schedules shown below are for the next available departures.


6h 22m • 2 changes


5h 42m • 2 changes
Arrives next day


9h 10m • 2 changes


6h 22m • 2 changes


5h 42m • 2 changes
Arrives next day


9h 10m • 2 changes


6h 22m • 2 changes


5h 42m • 2 changes
Arrives next day


9h 10m • 2 changes


6h 22m • 2 changes


5h 42m • 2 changes
Arrives next day


9h 40m • 2 changes


6h 22m • 2 changes


8h 22m • 2 changes
Arrives next day


9h 55m • 2 changes
Want to know about travelling from Santillana del Mar to San Sebastián de los Reyes? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santillana del Mar to San Sebastián de los Reyes. However, there are services departing from Santillana del Mar station and arriving at San Sebastián de los Reyes station via Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid). The journey, including transfers, takes approximately 7h 19m.
Santillana del Mar to San Sebastián de los Reyes bus services, operated by ALSA, depart from Torrelavega station.
Santillana del Mar to San Sebastián de los Reyes bus services, operated by ALSA, arrive at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) station.
The distance between Santillana del Mar and San Sebastián de los Reyes is 317.7 km. The road distance is 387 km.
ALSA operates a bus from Torrelavega to Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) 5 times a day. Tickets cost €30–50 and the journey takes 4h 55m.