The average bus between Seattle and South San Francisco takes 23h 9m and the fastest bus takes 21h 59m. The bus service runs several times per day from Seattle to South San Francisco. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Seattle and South San Francisco. The earliest departure is at 2:10 PM in the afternoon, and the last departure from Seattle is at 9:15 PM which arrives into South San Francisco at 7:14 PM. All services require a transfer at Sacramento Bus Station and take an average of 23h 9m. The schedules shown below are for the next available departures.
Arrives next day


23h 27m • 2 changes
Arrives next day


21h 59m • 2 changes
Arrives next day


23h 27m • 2 changes
Arrives next day


21h 59m • 2 changes
Arrives next day


23h 27m • 2 changes
Arrives next day


21h 59m • 2 changes
Arrives next day


23h 41m • 2 changes
Arrives next day


22h 1m • 2 changes
Want to know about travelling from Seattle to South San Francisco? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Seattle to South San Francisco. However, there are services departing from Seattle station and arriving at South San Francisco station via Sacramento Bus Station station. The journey, including transfers, takes approximately 23h 9m.
Seattle to South San Francisco bus services, operated by Greyhound USA, depart from Seattle Bus Station.
Seattle to South San Francisco bus services, operated by Greyhound USA, arrive at San Francisco Bus Station.
The distance between Seattle and South San Francisco is 1,106.6 km. The road distance is 1,388 km.
You can take a bus from Seattle Bus Station to Airport Blvd & E Grand Ave via Sacramento Bus Station and Mission St & 1st St in around 22h 4m.