The average bus between Setauket and Holtsville takes 1h 41m and the fastest bus takes 1h 17m. There is a bus service every few hours from Setauket to Holtsville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Setauket and Holtsville. The earliest departure is at 6:46 AM in the morning, and the last departure from Setauket is at 10:53 PM which arrives into Holtsville at 6:09 AM. All services require a transfer, and take on average 1h 41m. The schedules shown below are for the next available departures.

1h 23m • 1 change

1h 22m • 1 change

1h 22m • 1 change

1h 20m • 1 change

1h 23m • 1 change

1h 23m • 1 change

1h 20m • 1 change

1h 23m • 1 change

1h 23m • 1 change

1h 23m • 1 change

1h 20m • 1 change

1h 23m • 1 change

1h 23m • 1 change

1h 23m • 1 change

1h 20m • 1 change

1h 23m • 1 change
Want to know about travelling from Setauket to Holtsville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Setauket to Holtsville. However, there are services departing from Setauket station and arriving at Holtsville station via NYS 112/Cherub Ln. The journey, including transfers, takes approximately 1h 41m.
Setauket to Holtsville bus services, operated by Suffolk County Transit, depart from NYS 25A/The Hills Dr station.
Setauket to Holtsville bus services, operated by Suffolk County Transit, arrive at Waverly Ave/Long Island Ave station.
The distance between Setauket and Holtsville is 14.7 km. The road distance is 24 km.
You can take a bus from NYS 25A/The Hills Dr to Waverly Ave/Long Island Ave via NYS 112/Cherub Ln in around 1h 33m.