Setauket to Holtsville Buses

Trip Overview

The average bus between Setauket and Holtsville takes 1h 42m and the fastest bus takes 1h 17m. There is a bus service every few hours from Setauket to Holtsville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

1h 42m
Duration: 15 mi
Distance: $5
Average price: Hourly
Frequency

Line 51 bus, line 53 bus

best

Take the bus from NYS 25A/The Hills Dr to NYS 112/Cherub Lnbus 51
Take the bus from NYS 112/Cherub Ln to Waverly Ave/Long Island Avebus 53

1h 33m

Setauket to Holtsville bus times

Buses run hourly between Setauket and Holtsville. The earliest departure is at 6:46 AM in the morning, and the last departure from Setauket is at 10:53 PM which arrives into Holtsville at 6:08 AM. All services require a transfer, and take on average 1h 42m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

5:48 PM → 7:09 PM
1h 21m • 1 change
6:48 PM → 8:11 PM
1h 23m • 1 change
7:53 PM → 9:11 PM
1h 18m • 1 change
8:53 PM → 10:11 PM
1h 18m • 1 change
Show more

Departing Saturday, October 31, 2026

6:46 AM → 8:08 AM
1h 22m • 1 change
7:46 AM → 9:08 AM
1h 22m • 1 change
8:46 AM → 10:08 AM
1h 22m • 1 change
9:46 AM → 11:08 AM
1h 22m • 1 change
Show more

Departing Sunday, November 1, 2026

6:51 AM → 8:08 AM
1h 17m • 1 change
7:51 AM → 9:08 AM
1h 17m • 1 change
8:51 AM → 10:08 AM
1h 17m • 1 change
9:51 AM → 11:08 AM
1h 17m • 1 change
Show more

Departing Monday, November 2, 2026

6:46 AM → 8:09 AM
1h 23m • 1 change
7:46 AM → 9:09 AM
1h 23m • 1 change
8:46 AM → 10:06 AM
1h 20m • 1 change
9:46 AM → 11:09 AM
1h 23m • 1 change
Show more

Departing Tuesday, November 3, 2026

6:46 AM → 8:09 AM
1h 23m • 1 change
7:46 AM → 9:09 AM
1h 23m • 1 change
8:46 AM → 10:06 AM
1h 20m • 1 change
9:46 AM → 11:09 AM
1h 23m • 1 change
Show more

Departing Wednesday, November 4, 2026

6:46 AM → 8:09 AM
1h 23m • 1 change
7:46 AM → 9:09 AM
1h 23m • 1 change
8:46 AM → 10:06 AM
1h 20m • 1 change
9:46 AM → 11:09 AM
1h 23m • 1 change
Show more

Departing Thursday, November 5, 2026

6:46 AM → 8:09 AM
1h 23m • 1 change
7:46 AM → 9:09 AM
1h 23m • 1 change
8:46 AM → 10:06 AM
1h 20m • 1 change
9:46 AM → 11:09 AM
1h 23m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Setauket to Holtsville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Setauket to Holtsville buses

Find Transport to Holtsville

Trip Overview

Line 51 bus, line 53 bus

Setauket to Holtsville bus times

Departing Friday, October 30, 2026

5:48 PM → 7:09 PM

6:48 PM → 8:11 PM

7:53 PM → 9:11 PM

8:53 PM → 10:11 PM

Departing Saturday, October 31, 2026

6:46 AM → 8:08 AM

7:46 AM → 9:08 AM

8:46 AM → 10:08 AM

9:46 AM → 11:08 AM

Departing Sunday, November 1, 2026

6:51 AM → 8:08 AM

7:51 AM → 9:08 AM

8:51 AM → 10:08 AM

9:51 AM → 11:08 AM

Departing Monday, November 2, 2026

6:46 AM → 8:09 AM

7:46 AM → 9:09 AM

8:46 AM → 10:06 AM

9:46 AM → 11:09 AM

Departing Tuesday, November 3, 2026

6:46 AM → 8:09 AM

7:46 AM → 9:09 AM

8:46 AM → 10:06 AM

9:46 AM → 11:09 AM

Departing Wednesday, November 4, 2026

6:46 AM → 8:09 AM

7:46 AM → 9:09 AM

8:46 AM → 10:06 AM

9:46 AM → 11:09 AM

Departing Thursday, November 5, 2026

6:46 AM → 8:09 AM

7:46 AM → 9:09 AM

8:46 AM → 10:06 AM

9:46 AM → 11:09 AM

Frequently asked questions

What companies run services between Setauket, NY, USA and Holtsville, NY, USA?

Bus from NYS 25A/The Hills Dr to NYS 112/Cherub Ln

Bus from NYS 112/Cherub Ln to Waverly Ave/Long Island Ave

Bus trips from Setauket

Bus trips to Holtsville

Alternative transport options