The average bus between Sherman Oaks and La Mesa takes 6h 32m and the fastest bus takes 5h 28m. The bus service runs several times per day from Sherman Oaks to La Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Sherman Oaks and La Mesa. The earliest departure is at 7:19 AM in the morning, and the last departure from Sherman Oaks is at 7:25 PM which arrives into La Mesa at 6:51 AM. All services require a transfer at Universal / Studio City Station and take an average of 6h 32m. The schedules shown below are for the next available departures.




6h 28m • 4 changes




5h 56m • 4 changes




6h 1m • 4 changes




6h 3m • 4 changes




5h 28m • 4 changes




5h 56m • 4 changes




6h 1m • 4 changes




6h 3m • 4 changes




5h 28m • 4 changes




5h 56m • 4 changes




6h 1m • 4 changes




6h 3m • 4 changes




5h 28m • 4 changes




5h 56m • 4 changes




6h 1m • 4 changes




6h 3m • 4 changes
Want to know about travelling from Sherman Oaks to La Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Sherman Oaks to La Mesa. However, there are services departing from Sherman Oaks station and arriving at La Mesa station via San Diego. The journey, including transfers, takes approximately 6h 32m.
Sherman Oaks to La Mesa bus services, operated by Metro Los Angeles, depart from Los Angeles Union Station.
Sherman Oaks to La Mesa bus services, operated by Metro Los Angeles, arrive at San Diego station.
The distance between Sherman Oaks and La Mesa is 202.9 km. The road distance is 248 km.
Greyhound Mexico operates a bus from Los Angeles Union Station to San Diego 3 times a day. Tickets cost $23–40 and the journey takes 2h 55m.