Siena Cathedral to Rome Buses

Siena Cathedral to Rome buses

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Trip Overview

The average bus between Siena Cathedral and Rome takes 3h 25m and the fastest bus takes 2h 55m. The bus service runs several times per day from Siena Cathedral to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 25m
Duration: 233 km
Distance: €21
Average price: Every 4 hours
Frequency

Bus

best

Take the bus from Siena to Roma, Autostazione Tiburtinabus 1520 / ...

3h 52m

€17–31

Siena Cathedral to Rome bus times

Buses run every 4 hours between Siena Cathedral and Rome. The earliest departure is at 5:34 AM in the morning, and the last departure from Siena Cathedral is at 9:34 PM which arrives into Rome at 1:10 AM. All services require a transfer at SIENA-P.za SAN DOMENICO and take an average of 3h 25m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

10:25 AM → 1:35 PM
3h 10m • 1 change
12:25 PM → 3:20 PM
2h 55m • 1 change
2:39 PM → 5:45 PM
3h 6m • 1 change
3:25 PM → 6:35 PM
3h 10m • 1 change
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Departing Saturday, November 7, 2026

6:29 AM → 9:55 AM
3h 26m • 1 change
8:16 AM → 11:25 AM
3h 9m • 1 change
10:25 AM → 1:35 PM
3h 10m • 1 change
12:25 PM → 3:20 PM
2h 55m • 1 change
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Departing Sunday, November 8, 2026

5:34 AM → 9:55 AM
4h 21m • 1 change
8:08 AM → 11:25 AM
3h 17m • 1 change
10:09 AM → 1:35 PM
3h 26m • 1 change
12:09 PM → 3:20 PM
3h 11m • 1 change
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Departing Monday, November 9, 2026

6:29 AM → 9:55 AM
3h 26m • 1 change
8:16 AM → 11:25 AM
3h 9m • 1 change
10:25 AM → 1:35 PM
3h 10m • 1 change
12:25 PM → 3:20 PM
2h 55m • 1 change
Show more

Departing Tuesday, November 10, 2026

6:29 AM → 9:55 AM
3h 26m • 1 change
8:16 AM → 11:25 AM
3h 9m • 1 change
10:25 AM → 1:35 PM
3h 10m • 1 change
2:39 PM → 5:45 PM
3h 6m • 1 change
Show more

Departing Wednesday, November 11, 2026

6:29 AM → 9:55 AM
3h 26m • 1 change
8:16 AM → 11:25 AM
3h 9m • 1 change
10:25 AM → 1:35 PM
3h 10m • 1 change
12:25 PM → 4:45 PM
4h 20m • 1 change
Show more

Departing Thursday, November 12, 2026

6:29 AM → 9:55 AM
3h 26m • 1 change
8:16 AM → 11:25 AM
3h 9m • 1 change
10:25 AM → 1:35 PM
3h 10m • 1 change
2:39 PM → 5:45 PM
3h 6m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Siena Cathedral to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.