The average bus between Siena and Avignon takes 18h 50m and the fastest bus takes 16h 55m. The bus service runs several times per day from Siena to Avignon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Siena and Avignon. The earliest departure is at 11:40 AM in the morning, and the last departure from Siena is at 8:25 PM which arrives into Avignon at 1:20 PM. All services require a transfer at Florence Villa Constanza Bus Station and take an average of 18h 50m. The schedules shown below are for the next available departures.
Arrives next day


20h 45m • 2 changesArrives next day


16h 55m • 2 changesArrives next day


20h 45m • 2 changesArrives next day


16h 55m • 2 changesArrives next day


20h 45m • 2 changesArrives next day


16h 55m • 2 changesArrives next day


20h 45m • 2 changesArrives next day


16h 55m • 2 changesWant to know about travelling from Siena to Avignon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Avignon. However, there are services departing from Siena station and arriving at Avignon station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 18h 50m.
Siena to Avignon bus services, operated by FlixBus, depart from Siena station.
Siena to Avignon bus services, operated by FlixBus, arrive at Avignon - Le Pontet - Le Lac Stop station.
Book your Siena to Avignon bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Siena and Avignon is 529.4 km. The road distance is 798 km.
You can take a bus from Siena to Avignon - Le Pontet - Le Lac Stop via Florence Villa Constanza Bus Station and Marseille - Saint-Charles Bus Station in around 13h 5m.