The average bus between Siena and Canton of Lucerne takes 12h 20m and the fastest bus takes 9h 40m. The bus service runs several times per day from Siena to Canton of Lucerne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Siena and Canton of Lucerne. The earliest departure is at 12:45 AM at night, and the last departure from Siena is at 6:40 PM which arrives into Canton of Lucerne at 2:20 AM. All services require a transfer at Florence Villa Constanza Bus Station and take an average of 12h 20m. The schedules shown below are for the next available departures.

10h • 1 change
Arrives next day

9h 5m • 1 change
Arrives next day

7h 40m • 1 change

13h 40m • 1 change
Arrives next day

9h 5m • 1 change
Arrives next day

8h 55m • 1 change
Want to know about travelling from Siena to Canton of Lucerne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Canton of Lucerne. However, there are services departing from Siena station and arriving at Canton of Lucerne station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 12h 20m.
Siena to Canton of Lucerne bus services, operated by FlixBus, depart from Siena station.
Siena to Canton of Lucerne bus services, operated by FlixBus, arrive at Luzerner Raststätte A2 station.
Book your Siena to Canton of Lucerne bus tickets online with FlixBus and RegioJet.
The distance between Siena and Canton of Lucerne is 486.9 km. The road distance is 652 km.
You can take a bus from Siena to Lucerne via Florence Villa Constanza Bus Station and Luzerner Raststätte A2 in around 6h 43m.